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Methods Animal experiment Male SHR and WKY rats, aged 2, 3, 4, 6, 8, 10, 12 and 16 weeks, were obtained from the Laboratory Animals Research Unit of Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia and housed at room temperature with a 1212 h lightdark cycle (06001800 hours), and with access ad libitum to food and water throughout the experimental period

Contraindications and precautions include personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, history of pancreatitis (requires careful consideration), severe gastrointestinal disease, diabetic retinopathy (requires caution), and pregnancy or planned pregnancy

RESULTS Baseline Characteristics Between June 2019 and March 2021, a total of 9650 individuals were randomized (4825 per arm), of whom 2596 (26.9%) participants were receiving SGLT2i at baseline (1296 in the oral semaglutide and 1300 in the placebo group)

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