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Many tissues around the body have GLP-1 receptors (proteins that respond to the hormone) and recent research has suggested the drugs also have anti-inflammatory and antioxidant effects

Morning dosing in a fasted state (immediately upon waking, 1012 hours post-meal) takes advantage of low endogenous ghrelin and somatostatin, producing a robust growth hormone pulse within 3060 minutes

GLP-1 receptor agonists, compounds like semaglutide and tirzepatide , work through an entirely different pathway, mimicking an incretin hormone that controls appetite, insulin secretion, and gastric emptying

The hormonal and neurological changes that made sticking to a deficit easier disappear when you stop the medication

For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA)