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These included elevated methylation levels in CpG islands associated with FZD1 and RUNX3 , both of which encode proteins that regulate ovarian folliculogenesis [39, 40], and also RASAL3 , which controls a magnitude of inflammatory responses [41] and has been linked specifically to inflammatory bowel disease [42] (Fig S3D)

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Looking for calprotectin in the stool can indicate inflammatory bowel disease, such as Crohns or ulcerative colitis

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Moreover, no injury to the skin was observed after treatment in each group