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ABSTRACT Parkinsons disease (PD) is a severe neurodegenerative disease characterized by classic motor features associated with the loss of dopaminergic neurons and appearance of Lewy bodies in the substantia nigra

Common reasons for temporary discontinuation include: Gastrointestinal adverse effects Nausea, vomiting, diarrhea, and constipation are the most frequently reported side effects, particularly during dose escalation

Cell 167 , 739749 (2016)