To account for multiple testing in the data analysis and the dependence of BA measurements within each of the BA classes and SCFAs, the significance threshold was adjusted to P 0.01
S-Adenosylhomocysteine increases -amyloid formation in BV-2 microglial cells by increased expressions of -amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters
In particular, dysregulation of the gut-liver-muscle-brain axis, driven by hyperammonemia, systemic inflammation, sarcopenia, altered bile acid signaling, and gut dysbiosis, plays an important role in the pathogenesis and progression of CHE [9, 10]
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