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The second, and perhaps most relevant reason, is that the blood for neonatal screening is taken from neonates in the first days of life, a period crucial for the establishment of immunologic central tolerance in the thymus

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All three patients completed the full course of treatment and attended every scheduled session

Lawitz EJ, Fraessdorf M, Neff GW, Schattenberg JM, Noureddin M, Alkhouri N, Schmid B, Andrews CP, Takcs I, Hussain SA, Fenske WK, Gane EJ, Hosseini-Tabatabaei A, Sanyal AJ, Mazo DF, Younes R