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However, combining medications requires careful monitoring by a qualified clinician familiar with both drug classes

In 2022, researchers conducted the first systematic review and a series of meta-analyses that evaluated melatonins impact on people with sleep or mental health disorders, finding evidence that melatonin significantly improved sleep-onset latency and total sleep time

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Although demographic and clinical predictors of discontinuation have been assessed, 74 the underlying reasons for discontinuation remain poorly quantified