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PT-141 is the MC4R-selective derivative of Melanotan II, has a stronger effect on sexual function, but has no effect on pigmentation

The growth hormone secretagogue receptor subtype 1a , is a Gq/11-coupled GPCR expressed at highest density in pituitary somatotroph cells and hypothalamic arcuate nucleus neurones, with peripheral expression in stomach, heart, liver, adipose tissue, and immune cells

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Long-term use requires careful monitoring to avoid hormonal imbalances or other risks