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To identify phenotypes, processes, and pathways associated with metabolites related to the analyzed drugs, we performed gene enrichment analysis on the selected metabolite lists

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Glutathione metabolism consists, in large part, of its oxidation to the disulfide and recycling to the reduced form by the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH) by mediation of glutathione reductase (Figure 1)