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Other established risk factors include: Hyperlipidemia Metabolic syndrome Obesity Atrial fibrillation Chronic kidney disease Sedentary lifestyle Sleep disorders, particularly obstructive sleep apnea Sleep disorders may contribute to CSVD through intermittent hypoxia, sympathetic activation, endothelial dysfunction, and impaired glymphatic clearance

What we are looking at is not really a drug story at all

Relative risk and absolute risk look very different

introduced Zr into a manganese porphyrin-based MOF (Mn-MOF) to construct a biocompatible nanosensitizer along with the capacity of GSH exhaustion-enhanced ferroptosis (Figure 5F) (Xu et al., 2021)