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These conditions may include, but are not limited to: A family history of eye problems Any active infection Iron or folic acid deficiency Kidney disease Liver disease Alcohol: Avoid drinking large amounts of alcohol while getting Vitamin B12 treatment

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Given the high frequency of musculoskeletal problems in individuals with clEDS (Supplementary Table 1), we propose that coordination of care and follow-up for patients with clEDS lie with (pediatric) rheumatology and if available with specialized EhlersDanlos services

Dietary context significantly impacts results