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Among these infiltrating cells, macrophages in synovial tissue, as an early cell subpopulation to enter the joint and synovial area, are the main contributors of tumor necrosis factor (TNF), profoundly mediating the chronic development of RA [49]

Semaglutide is not currently licensed for use in children under the age of 12, and safety evidence for its use in high-risk geriatric groups is limited [16]

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