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2019;364(6438):eaav2501
Several preclinical studies have shown that Quer in the myocardium can enhance the GSH antioxidant system by regulating multiple upstream molecular targets, such as peroxisome proliferator-activated receptor-gamma (PPAR-), phosphatidylinositide 3-kinase (PI3K)/serine/threonine kinase (AKT), and Nrf2 [120, 123, 124]
They may remain normal in GSTT1 null individuals if exposures are low and other detox systems compensate, and they can be abnormal in GSTT1 present individuals if toxic load or other stresses are high
However, sometimes discontinuation may be necessary or preferable for people using the medication
Your GP or diabetes specialist will provide guidance on timing the transition and monitoring your blood glucose levels during the changeover period to ensure continued glycaemic control
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