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Similarly, Long COVID, a condition with significant clinical overlaps with ME/CFS (Komaroff and Lipkin, 2023), patients showed marked improvements in fatigue scores as measured by the Chalder Fatigue Questionnaire in a randomized, double-blind, placebo-controlled trial using AXA1125

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To further explore the substrate scope of arGSTs, additional yeast systems were engineered using a one-plasmid strategy containing genes encoding dihydroflavonol-4-reductase (DFR), LDOX, a range of arGST and non-arGSTs (as negative controls) and anthocyanidin-3- O -glucosyl transferase (A3GT) (Fig