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Chronic elevations in blood pressure lead to structural changes within small vessel walls, including arteriosclerosis, endothelial dysfunction, impaired autoregulation, and blood-brain barrier disruption

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The intravenously administered preparation of golimumab, marketed as Simponi Aria by Janssen, has also been approved for the treatment of PsA, based on the 24-week GO-VIBRANT study

It's also what makes the ingredient effective at genuine remodelling rather than just adding new collagen on top of old