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Hence, ongoing research in PCa is focused on developing peptide-based immunotherapies aimed at reversing NK cell exhaustion and enhancing their cytotoxic functions

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Historically, HLA-DRB1 alleles have been the primary focus for the evaluation of immunity, disease, and immunogenicity given its ubiquitous presence in all APCs and high level of expression relative to the other HLA class II loci 5,6

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