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Understanding your genetic predispositions helps your PlexusDx provider anticipate your likely dose range and optimize therapy from the start, potentially reducing trial-and-error adjustments
A post hoc calculation of reduction in overall mass (fat mass plus lean body mass) in the DXA substudy indicated reductions of 5.7 kg vs 4.1 kg for semaglutide and canagliflozin, respectively
Although a single RCT failed to observe a statistically significant improvement in HOMA-IR (85), this discrepancy is more likely attributable to limited sample sizes, restricted follow-up windows, and heterogeneity in baseline metabolic phenotypes rather than a lack of efficacy
Interestingly, the accumulation of native amylin aggregates in the pancreas may itself contribute to beta-cell death in T2D, making amyloidogenicity both a formulation problem and a potential disease mechanism
Rather than focusing on a single mechanism, researchers are exploring a variety of compounds that may provide insight into how cells produce, regulate, and utilize energy
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