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Bioavailability data for subcutaneous versus oral routes in humans does not exist

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This approach emerged pragmatically from research schedules but aligns well with receptor recovery kinetics and avoids the potential tolerance development that continuous daily dosing over many weeks might produce

Olanow CW, Factor SA, Espay AJ, Hauser RA, Shill HA, Isaacson S, Pahwa R, Leinonen M, Bhargava P, Sciarappa K, Navia B, Blum D, investigators CTHS (2020) Apomorphine sublingual film for off episodes in Parkinsons disease: a randomised, double-blind, placebo-controlled phase 3 study