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What to watch for: Darkening of existing moles nearly universal with continued use Increased mole count new melanocytic nevi can appear Asymmetry or border changes these require immediate dermatological evaluation Darkening of areolas, genitals, and lips areas with high melanocyte density A systematic review of MT-2 case reports found that mole changes were among the most frequently reported dermatological effects, with four case reports describing melanomas emerging during or shortly after MT-2 use (Brennan et al., 2017)

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