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With two receptors this is hard

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[DOI] [PMC free article] [PubMed] [Google Scholar] 157.Miller T.E., Myles P.S

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If side effects were the issue, other GLP-1 receptor agonists with different formulations (such as once-weekly injectable semaglutide, dulaglutide, or liraglutide) may be better tolerated, though gastrointestinal effects are common across this drug class