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The compound is a potent dual agonist on hMC3R (EC 50 = 0.073 nM, E max = 96%) and hMC4R (EC 50 = 0.042 nM, E max = 101%) ( This novel approach to melanocortin receptor selectivity for weight loss was informed by our previous work demonstrating that co-administration of an MC4R-selective agonist and an MC3R-selective agonist caused a greater reduction in food intake and body weight in DIO NHPs than administration of either compound alone, yielding 7.8% weight loss after 36 days ( The role of dual agonism is further emphasized by 710GO, which displays agonist activity on both MC3R and MC4R

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^ Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure

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