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All models included participants' gender, ages, mothers' ages, fathers' ages, and races as covariates

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PLoS ONE 8:e66639 Kim JH, Jin S, Eo H, Oh MS, Lim Y (2023) Two faces of catechol-O-methyltransferase inhibitor on one-carbon metabolism in Parkinsons disease: a meta-analysis

In this study, histopathological examination of both right sides in two groups was of great value not only in confirming the type of melasma but also adding another objective tool in evaluation of treatment response in two groups, it demonstrated a decrease in melanin in basal cell layer in epidermal types and in melanin and melanophages in dermis in mixed types in H and E and MF stained sections after treatment compared with baseline

Without that data, we simply don't have a complete picture of its side effects, optimal dosing, or long-term health impacts in humans