Many widely used medications were never FDA-approved for the conditions they treat
In 2020, the FDA approved the use of Saxenda for treating obesity in children as young as 12 years old
Rodriguez noted the following areas of continued research to Medical News Today : There is still so much to learn about this class of medication, including how it can help to treat other conditions, long-term clinical outcomes, barriers to equitable access, the effects of discontinuation, trends in reinitiation, which dose of each drug might be most effective (pharmacodynamics), and more. In fact, we continue to explore the trends in prescriptions and dispense in our quarterly GLP-1 monitoring report, which looks at these trends over time and might provide some insight into access and availability, she continued
In a key study, obese or overweight participants without diabetes lost an average of 5.5 kilograms over a year
Notably, IFN- can trigger pyroptosis in macrophage within the ovaries, which disrupts of estrogen production and promotes apoptosis of GCs, and ultimately leading to the abnormal ovarian function in PCOS mice
