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A 20 percent LDL reduction from a weight-loss-oriented triple agonist is therefore a genuinely new observation and helps explain why retatrutide is being developed across cardiovascular, metabolic, and weight-related indications rather than as a pure obesity asset

"The fact that Wegovy is the only weight loss medicine proven to reduce the risk of heart attack, stroke, or cardiovascular death in patients with known heart disease and obesity makes this access moment particularly important for eligible Medicare beneficiaries." Joe Nadglowski, president and CEO of the Obesity Action Coalition, called the program a meaningful step forward while noting that more work remains

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