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Furthermore, NRF2 and PPAR engage in a reciprocal activation loop, enhancing each others transcription (Lee, 2017)

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BP and Cardiovascular Considerations The Phase 3 program documented modest, transient increases in systolic blood pressure (1.9-2.5 mmHg) and diastolic (1.7-1.8 mmHg) in the 4-6 hours after dosing