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CS acknowledges financial support from the Ministry of Education and Science of the Russian Federation, grant 14.Y26.31.0019

78 The half-life of PEG-loxenatide is approximately 1 week

It contains nutrients like astaxanthin, coenzyme Q10, levocarnitine, lycopene, and zinc which help enhance sperm function, sperm motility, and overall reproductive health

Given identical follow-up duration and labeled 4-week titration permitting escalation to 10 mg (tirzepatide) and 1.7 mg (semaglutide) by week 16, this difference likely reflects clinical titration patterns and differences in clinical effectiveness between the two treatments rather than limited time to escalate

In brief, animals ( n = 8 per group, per sex) were placed into individual cages at their standard temperature and photoperiod and allowed to acclimate for at least 72 h prior to the experiment, and data were collected over a 24 h period