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Initial dosing starts at 2.5 mg weekly for 4 weeks, then escalates to 5 mg, 7.5 mg, 10 mg, 12.5 mg, and a maximum of 15 mg, with monthly increases based on tolerance and weight loss response

90,91 If started at a young age, GH therapy, along with good dietary control, may delay obesity and fat mass and may prevent the development of the typical facial appearance

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The metabolic benefits they produce have implications for cardiovascular disease, liver health, diabetes management, and more

In a controlled colesevelam trial in 30 patients with IBS-D, colesevelam did not alter mucosal permeability (179)