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A deeper exploration of these biomarkers could lead to more comprehensive evaluation of ferroptosis-inducing strategies, such as targeting GPX4 with inhibitors like RSL3 in cancer therapy or modulating TFR1-mediated iron uptake in tumor cells [68, 69] 3.3 Tumour micro environment (TME)-driven oxidative stress and its impact on antioxidant therapy A tumour microenvironment contains multiple components which include cancer cells, stromal cells alongside immune cells and extracellular matrix (ECM) with various signalling molecules [70]

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doi: 10.1007/bf01963567 15 GerverWJDe BruinRDelemarre v d WaalHAAldewereldBTheunissenPet al

Nat Commun 16 , 2597 (2025)