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For negative controls for western blots, samples containing only embryos and surrounding follicle cells from stages before Buchnera colonization were collected from five aphids

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Single-cell RNA sequencing study identified that AGE-induced epigenetic modifications in retinal endothelial cells enhance the expression of VEGF and interleukin-6 (IL-6), contributing to BRB breakdown (73)

Common side effects include gastrointestinal symptoms (nausea, vomiting, diarrhoea), allergic reactions (rash, bronchospasm in people with asthma), anaphylactoid reactions with intravenous use, and headache particularly when used with nitrates

However, over the long term, dietary supply of adequate amounts of GSH precursors or GSH itself is required to prevent deficiency