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Suspected neurological involvement due to B12 deficiency warrants urgent initiation of treatment and may require specialist referral

Also, a slight but statistically significant decrease was observed in IL-6 and TNF-alpha levels

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The commenter recommended that CMS consider a volume threshold of 500 single major claims (or the existing greater or equal to 99 claims that constitute greater than or equal to the 2 percent criterion) as the standard for designating an item or service significant for purposes of the 2 times rule

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