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Treatment begins with a low dose that is increased gradually based on tolerance and response

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Protocol 3: every other day Every-other-day dosing creates an alternating schedule that some researchers find more natural than fixed days

The common gastrointestinal side effects of GLP-1 receptor agonists - nausea, vomiting, diarrhea, constipation - are mediated by the drugs effects on the GI tract and brain, which should be the same regardless of whether the semaglutide or tirzepatide was produced by a commercial manufacturer or a compounding pharmacy