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The activation of circulating platelets further influences leukocyte activity and participates in inflammation formation in RA patients (170)

Monitoring and Labs for Kidney Protection Routine labs ensure efficacy and safety: Urine ACR: At least annually, or more often if elevated eGFR: Baseline and periodic monitoring Electrolytes and BP: Especially after starting SGLT2 therapy HbA1c: To assess overall glycemic trends An early dip in eGFR after starting SGLT2 inhibitors is expected and often transient

Annals of the rheumatic diseases

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Acetylcholine (ACh) levels decrease in the brain