The native GLP-1 hormone is released from intestinal L-cells after food intake and helps regulate glucose-dependent insulin secretion, glucagon suppression, gastric emptying, and satiety signaling
Kim H, Baek KH, Lee SY, Ahn SH, Lee SH, Koh JM, et al
In diabetic mice, semaglutide alleviated anxiety- and depression-like behaviors and improved cognitive performance via modulation of the microbiota-gut-brain axis ( In summary, accumulating evidence supports the potential of GLP-1RAs in treating neurodegenerative and psychosocial disorders
It offers several benefits, like promoting weight loss and improving metabolic health
Inhibition of the glutamate forming enzyme glutamate carboxypeptidase II (GCP II), may help prevent both peripheral and central nervous system damage during chemotherapy and has been proposed as a possible treatment for amyotrophic lateral sclerosis (ALS), stroke, and even Multiple Sclerosis plus other neuropsychiatric diseases (Rahn et al, 2012)
