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Of these 50 semaglutide-treated patients that developed anti-semaglutide antibodies, 28 patients (1.6% of the overall population) developed antibodies cross-reacting with native GLP-1.The in vitro neutralizing activity of the antibodies is uncertain at this time

However, the quantification was not specific to LC-MS/MS platforms Need for developed and validated LC-MS/MS assay methods for peptides, which can be successfully applied for clinical study sample analysis

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