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Document baseline weight and body composition if possible

A recent clinical trial found that adding the glucagon-like peptide 1 (GLP-1) drug tirzepatide to the biologic ixekizumab helped 30 percent of adults with active psoriatic arthritis (PsA) who had overweight or obesity better control their symptoms while also losing weight

With respect to glycolysis in obese adipocytes, a decrease in glucose 6-phosphate accompanied by increased intracellular glucose levels was observed, which implied hexokinase as a possible major rate-limiting step in the provision of glucose carbons required for TG synthesis [32]

Patients need personalized nutrition guidance that addresses their individual biochemistry and accounts for their preferences, along with intensive support for behavior change