Then the mixture was extracted overnight and centrifuged at 10,000 r/min and 4 C to obtain the supernatant for HPLC analysis
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Ponziani FR, Zocco MA, Cerrito L, Gasbarrini A, Pompili M
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More importantly, higher advanced glycation end-products (CML and CEL) were found in fructose-fed rats, in line with previous works showing that fructose can lead to the formation of highly reactive intermediate products as -dicarbonyls [73], which in turn can favor the formation of advanced glycation end-products, as CML and CEL [74], thus acting as potent glycating agent [75] and negatively impacting the brain function [13, 76, 77]
