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Rutin specifically downregulated phosphorylated JNK1/2, while quercetin demonstrated a more substantial inhibitory effect on multiple mitogen-activated protein kinase (MAPK) pathway proteins, including extracellular signal-regulated kinases (ERKs) and p38 (Siti et al., 2021b)

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[21, 43] A 1 mL syringe (BD) equipped with a 40 mm, 21-gauge needle was mounted onto a syringe pump configured to deliver fluid at a controlled volumetric flow rate based on the barrel diameter

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