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Real-world effectiveness Studies examining real-world outcomes show that results are typically somewhat lower than in clinical trials but still significant: A 2025 Cleveland Clinic study found average weight loss of 10-15% in routine clinical practice (compared to 15-22% in trials)

In contrast, the persistent effects of longer-acting GLP-1RAs offer 24-h glucose control, including fasting glucose [53]

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[3] Citrulline itself has demonstrable hemodynamic benefits that extend beyond substrate recycling