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Discontinuation rates due to adverse events are 4.3-7.1% for tirzepatide versus 24.6% for survodutide

2017 Jun 15;12(6):e0179538

However, previous reviews emphasize common mechanistic pathways such as inflammation and oxidative stress while emerging pathways particularly autophagy-related signaling are under explored

Consistent with our Ki67 results we also see increased BrdU-ir cells at 2 hours in males compared with females, but no differences at 24 hours, which likely has to do with the population that Ki67 labels versus the pulsatile BrdU (Kee et al., 2002)

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