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The physician should provide information to the patient about the signs and symptoms of hepatotoxiciy that should cause alarm (e.g., nausea, fatigue, lethargy, pruritus, jaundice, right upper quadrant tenderness and "flu-like" symptoms)

In the second step, the resolving cysteine of one Prx subunit attacks the peroxidatic cysteine-sulfenic acid of the other subunit generating an inter-subunit disulfide bond [46, 75]

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