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216,217 Exendin-4 was also demonstrated to increase lysosomal function in another study, whereby autophagosome clearance in a rat model of tacrolimus-induced diabetes was increased, promoting cell survival given that autophagosome accumulation causes intracellular damage

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GoF receptors are often characterised by a greater propensity for G protein versus -arrestin recruitment and signalling, slower rate of receptor internalisation and rapid recycling back to the plasma membrane, with these characteristics being independent of their surface expression levels (Liu et al., 2022)

For dual receptor agonists, trials provide measurable data on blood sugar control, weight loss, metabolic improvements, and potential side effects, guiding dosage and patient selection

Laura Pags, Aina Mart-Carretero, Clara Sabiote, Farnaz Faninam, Sophia C