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3 Ferroptosis and neurodegenerative diseases Iron is an essential trace element for maintaining brain function, playing vital roles in neuronal development, neurotransmitter synthesis, mitochondrial energy metabolism, myelin formation, and synaptic plasticity (Table 1), suggesting that therapeutic targeting of ferroptosis may offer a promising strategy for the prevention and treatment of NDDs

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Oxidative stress and ageing: is ageing a cysteine deficiency syndrome

We first tested if PSR-1 puncta could be affected by 1, 6-Hexanediol (1,6-HD), an aliphatic alcohol that has been routinely used to disrupt multivalent hydrophobic protein-protein interactions to disassemble phase-separated droplets 60,61

Biochim Biophys Acta