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A 2022 patient-preference study found that 41% of patients preferred manual pens because they wanted control over insertion speed, and 28% reported that the autoinjector's spring-loaded mechanism caused more injection-site pain than manual insertion (Schiff et al., Rheumatology and Therapy , 2022)

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About 9-10% of participants stopped treatment because of side-effects mainly gastrointestinal issues compared with 4-5% in the semaglutide groups