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In particular, cell cycle, inflammation, hemostasis and platelets, ER stress and proteasome, amino acid and purine metabolism, DNA damage and apoptosis gene sets were down-regulated in livers from M+Fc-GLP-1 versus MCD mice, suggesting that multiple pathways dysregulated in NASH were modulated by Fc-GLP-1 treatment (Fig

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Whilst these trials primarily enrolled participants without diabetes, the findings are relevant for understanding semaglutide's weight-loss potential when used at higher doses