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The amount of weight lost before plateauing and the timing of the plateau differ among individuals, influenced by genetics, baseline weight, medication dose, and lifestyle factors

Treatment should only be continued if there has been a beneficial metabolic response, defined as a reduction in HbA1c of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight

In other words, the people with access to these drugs had other protective factors against dementia

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