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1.5 grams per day showed significant mean increases in a physical working capacity at the fatigue threshold (PWCFT) test [13] This is a biometric-based electromyographic test used to estimate the greatest power output one can maintain without showing neuromuscular signs of fatigue

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And in a recent 2023 study of Zepbound, 9.4% of participants reported headachebut so did 7.5% of people who were taking a placebo