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Animal studies also suggest that TMAO can impair glucose tolerance and exacerbate insulin resistance via inflammatory pathways [9]

n= 2851) as add-on therapy to metformin (85% of individuals) and/or sulfonylureas (74% of individuals) showed that GLP-1RA combination therapy was associated with a lower risk of MACE (HR 0.64 [95% CI 0.43, 0.97]) and all-cause death (HR 0.53 [95% CI 0.35, 0.79]) compared with DPP4i, but not with SGLT2i

Halal Research Center of IRI, FDA, Tehran, Iran

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