fda glp-1 warning news november 2025 Pharmacovigilance Assessment of Compounded Receptor Agonists: Insights From the Adverse Event Reporting System Myths & Facts: GLP-1 Drugs

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GIP receptor signaling increases cAMP levels in the brain, which activates PKA and EPAC [102]

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In rodent experiments, GLP-1 receptor activity within the hypothalamus was associated with changes in TSH (thyroid-stimulating hormone) secretion and downstream thyroid hormone regulation

Despite these findings, to our knowledge, there are no large population-based studies that have investigated the incidence of new-onset major cardiovascular events or clinically significant portal hypertension events in patients with MASLD who are receiving treatment with GLP-1 agonists for any indication