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Unlike ascorbic acid, which is water-soluble, ascorbyl palmitate can cross cell membranes and other biological barriers

Further studies using virus-mediated gene knockout and chemogenetic approaches have confirmed that knocking out the Shank3 gene specifically in interneurons is sufficient to cause hyperexcitability in pyramidal neurons and sensory hypersensitivity (92)

However, researchers working with very small doses may prefer more dilute solutions, while those needing larger doses might opt for higher concentrations to minimise injection volumes