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(44) reported that the half-maximal effective concentrations (EC50) of GIP with GIPR and of GLP-1 with GLP-1R are 20 pM and 28 pM, respectively, without exhibiting cross-reactivity

10.1016/j.cell.2019.03.032 3 AlmahiW

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RAASis with the maximally recommended or maximally tolerated dose of ACEi or ARB are the standard of care for prevention and treatment of CKD in people with diabetes, and they provide benefit over and above the effect of controlling BP [13]